The FAQ states that tirzepatide is "generally prescribed for adults with a BMI of 30 or greater, or a BMI of 27 or greater with a weight-related condition like hypertension" and notes contraindications including personal or family history of medullary thyroid cancer, MEN 2, or pregnancy and breastfeeding
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Tirzepatide, a dual GIP and GLP-1 receptor agonist licensed for type 2 diabetes, and phentermine, an unlicensed sympathomimetic appetite suppressant, work through entirely different mechanisms
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Clinical trials show highly variable blood pressure responses: some patients experience modest elevation (typically 38 mmHg) during dose escalation, while others see decreases of 510 mmHg
From there, it's no surprise that the EC3 spread like wildfire